H. pylori infection




Helicobacter pylori, also known as H. pylori, is a bacterium that is commonly found in the stomach. It is present in approximately one-half of the world’s population.

The vast majority of people infected with H. pylori infection have no symptoms and will never develop problems. However, H. pylori is capable of causing a number of digestive problems, including ulcers, and, much less commonly, stomach cancer. It is not clear why some people with H. pylori get these conditions and others do not. READ THE ENTIRE ARTICLE

The effect of mastic gum on Helicobacter pylori: a randomized pilot study.
Dabos KJ, Sfika E, Vlatta LJ, Giannikopoulos G.
Department of Gastroenterology, Chios General Hospital Skylitsion, Helenas Venizalou 2, 82100 Chios, Greece. [email protected]
Our aim was to study the effect of pure mastic gum on Helicobacter pylori (H. pylori) eradication in patients suffering from an H. pylori infection Fifty two patients were randomized to receive either 350mg three times a day (tid) of pure mastic gum for 14 days (Group A), or 1,05g tid of pure mastic gum (Group B) for 14 days, or pantoprazole 20mg twice a day (bd) plus pure mastic gum 350mg tid for 14 days (Group C) or pantoprazole 20mg bd plus amoxicillin 1g bd plus clarithromycin 500mg bd for 10 days (Group D). All patients harboured H. pylori before entering the study and that was confirmed by a (13)C urea breath test (UBT). H. pylori eradication was tested by a UBT 5 weeks after completion of the eradication regime. Eradication of H. pylori was confirmed in 4/13 patients in Group A and in 5/13 in Grour B. No patient in Group C achieved eradication whereas 10/13 patients in Group D had a negative UBT. There were no statistically significant differences in mean UBT values in Groups A, B, C although there was a trend in Group A (p=0.08) and in Group B (p=0.064). The difference was significant in Group D (p=0.01). All patients tolerated mastic gum well and no serious adverse events were reported. Mastic gum has bactericidal activity on H. pylori in vivo.
Copyright 2009 Elsevier GmbH. All rights reserved. MORE: http://www.ncbi.nlm.nih.gov/pubmed/19879118